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For Staff - Immunosuppressants in pregnant/breastfeeding women and live vaccines in babies

Babies born to mothers who received immunosuppressive biological therapy during pregnancy 

Immunisation with live vaccines should be delayed until 6 months of age in children born to mothers who received immunosuppressive biological therapy* during pregnancy. In practice, this means that children born to mothers who were on immunosuppressive biological therapy during pregnancy will not be eligible to receive rotavirus vaccine (and will need to defer BCG, if indicated, for 6 months). Specialist advice should be sought if there is any doubt as to whether an infant due to receive a live attenuated vaccine may be immunosuppressed due to the mother’s therapy. Contact the PHPU or the consultant specialist who is prescribing the medication. 

See the relevant section in the Rotavirus PGD and the BCG PGD 

Breast-fed babies whose mothers are receiving immunosuppressive biological therapy 

Specialist advice should also be sought for breast-fed babies who require a live vaccine, including MMR, and whose mothers are receiving immunosuppressive biological therapy. Contact the PHPU or the consultant specialist who is prescribing the medication.

 

* (e.g. Anti-TNF therapy such as alemtuzumab, ofatumumab, rituximab)

 

Page created October 2018