Thyroglobulin and Thyroglobulin Antibodies
Thyroglobulin (Tg), a protein produced by normal or malignant thyroid tissue, is used to monitor treatment of differentiated thyroid cancer and to detect recurrence. Tg measured a few months after total thyroidectomy for thyroid carcinoma provides valuable prognostic information.
Please note that recent thyroid biopsy or surgery will cause an increase in Tg.
15-20% of thyroid cancer patients have thyroglobulin antibodies (TgAb). If present, TgAb can interfere with Tg measurements causing an artefactually low result. TgAb status may alter during treatment and TgAb should therefore always be measured on all Tg samples.
Persistent or increasing concentrations of TgAb following thyroidectomy may indicate residual or recurrent tumour.
Tg measurement is also of use in establishing the presence or absence of thyroid tissue in neonates with congenital hypothyroidism.
Sample Requirements and Reference Ranges
|| Plain, SST
|| 2 mL
|| Not applicable
|| 7 days
|| Beckman Access