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COVID-19 (Coronavirus info)

Information and guidance for public, NHSGGC staff, and community-based services.  Hospital visiting restrictions now in place.

Thyroglobulin and Thyroglobulin Antibodies

Thyroglobulin (Tg), a protein produced by normal or malignant thyroid tissue, is used to monitor treatment of differentiated thyroid cancer and to detect recurrence. Tg measured a few months after total thyroidectomy for thyroid carcinoma provides valuable prognostic information. 
Please note that recent thyroid biopsy or surgery will cause an increase in Tg.
15-20% of thyroid cancer patients have thyroglobulin antibodies (TgAb). If present, TgAb can interfere with Tg measurements causing an artefactually low result. TgAb status may alter during treatment and TgAb should therefore always be measured on all Tg samples.
Persistent or increasing concentrations of TgAb following thyroidectomy may indicate residual or recurrent tumour.
Tg measurement is also of use in establishing the presence or absence of thyroid tissue in neonates with congenital hypothyroidism.
Sample Requirements and Reference Ranges
Sample type  Serum
Container  Plain, SST
Precautions  None
Minimum volume  2 mL
Reference range  Not applicable
Turnaround time  7 days
Method  Beckman Access
Quality Assurance
Last Updated: 23 April 2020