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Metadrenalines (urine)

The urine free metadrenaline profile:

  • Metadrenaline
  • Normetadrenaline
  • 3-methoxytyramine

Urine free metadrenalines are used for the diagnosis of catecholamine producing tumours including phaeochromocytoma or paraganglioma (PPGL). Patients with PPGL may present with episodes of hypertension with palpitations, severe headaches and sweating. Patients may be asymptomatic but have an incidentally discovered adrenal mass.

  
Sample Requirements and Reference Ranges
  
Sample type  24 hr urine
Container  Plain urine container (no preservative)
Precautions

 Certain medications may cause false elevations of urine metadrenalines (click here for full list). If clinically feasible, it is optimal to discontinue these medications at least 1 week before sample collection.

 Click here for patient information sheet for urine collection

Minimum volume  2 mL
Reference range

 Metadrenaline < 350 nmol/24 h

 Normetadrenaline < 650 nmol/24 h

 3-methoxytyramine < 400 nmol/24 h

Turnaround time  14 days
Method  Liquid chromatography-tandem mass spectrometry
 
Quality Assurance
RCPA
Last Updated: 22 June 2020