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Chromogranin A

Chromogranin A is an acidic 439 amino acid glycoprotein (48 kDa) originating from the chromaffin granules of most neuroendocrine cell types. In health, chromogranin A is released as a pro-hormone together with other peptide hormones in response to stimulation. Larger quantities of chromogranin A are produced by neuroendocrine derived tumours thus allowing it to be used as a tumour marker. Chromogranin A is the most commonly raised neuroendocrine tumour (NET) marker.

Please click here for guidance on which tumour markers to request during the diagnosis and monitoring of NETs.

  
Sample requirements and reference range
  
Sample type  Serum
Container  SST/Plain Serum
Precautions  Spin and separate within 8 hours. Store serum for up to four days refrigerated. Store frozen if longer term storage is required. Samples from referral laboratories can be posted at room temperature using 1st class post.
Minimum volume  1 mL
Reference range  <95 µg/L
Turnaround time  28 days
Method  CisBio ELISA
 
Quality Assurance
UK NEQAS
Last Updated: 28 November 2019