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CA125

CA125 (carbohydrate antigen 125) is a glycoprotein MW >200 kDa. It is present in tissues derived from the foetal coelomic epithelium. In adults it occurs on the pleura and peritoneum, the gastrointestinal tract and female reproductive tract, including the endometrium. CA125 may be increased in women at the time of menstruation, in endometriosis, benign ovarian disease and renal or liver disease, and may be very high in early pregnancy. It is also elevated in patients with ascites, a pleural effusion or CCF.
  
Measurement is usually restricted to monitoring the treatment of ovarian carcinoma. 
  
Sample Requirements and Reference Ranges
  
Sample type  Serum
Container  SST
Precautions  None 
Minimum volume  2 mL
Reference range

  ≤35 kU/L

Turnaround time  1 day
Method  Abbott Architect
 
Quality Assurance
UK NEQAS
Last Updated: 10 July 2020