Alpha-fetoprotein (AFP) is a 591 amino acid glycoprotein produced by the liver and yolk sac of a developing baby during pregnancy. Plasma concentrations begin decreasing at the end of the first trimester of pregnancy and fall rapidly after birth, with normal adult concentrations achieved by the age of 8 to 12 months. AFP is increased in neonates, during pregnancy and in some patients with benign liver disease.

   

AFP is usually measured to assist with diagnosis of primary hepatocellular carcinoma or non seminomatous germ cell tumour (NSGCT) and to monitor treatment or detect recurrent disease in patients with these tumours.

  

N.B.  Send AFP for maternal screening to Medical Genetics, QEUH.

   

Sample type	Serum
Container	SST
Precautions	None
Minimum volume	2 mL
Reference range	≤6 kU/L
Turnaround time	1 day
Method	Abbott Architect