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5 - Hydroxyindole Acetic Acid (5-HIAA) (urine)

Metastatic carcinoid tumours arising from enterochromaffin cells produce excessive amounts of serotonin. The main metabolite of serotonin, 5-hydroxyindole acetic acid (5-HIAA) is excreted in urine and its measurement can be used to diagnose and monitor carcinoid tumours.
  
Sample Requirements and Reference Ranges
  
Sample type  24 hr urine (acidified)
Container  24 hr urine container with 50 mL hydrochloric acid
Precautions

 Elevated by dietary walnuts, bananas, tomatoes, avocado, kiwi fruit,  pineapple, plantain, plums, pecan nuts. Avoid for 3-4 days prior to  starting urine collection.

 Click here for patient information sheet for urine collection

Minimum volume  2 mL
Reference range  ≤ 42 μmol/24 h
Turnaround time  14 days
Method  Liquid chromatography-tandem mass spectrometry
  
Quality Assurance
UK NEQAS
Last Updated: 24 July 2020