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Serum androgen profile

The serum androgen profile simultaneously measures:

11DOC and 21DOC are not routinely reported. If an abnormality is detected in either, a comment will be made on the report.

The androgen profile is recommended for investigation of hirsutism, polycystic ovarian syndrome (PCOS) and infertility in females, and for the diagnosis and monitoring of congenital adrenal hyperplasia (CAH) in both males and females. Please state clinical details and menstrual cycle information on the request form. 

Androgens pre- and 60-min post synacthen may be of benefit for the investigation of late onset CAH if elevated androgens have been observed in a follicular phase sample.

In neonates, 17OHP can be measured from the day of birth for the investigation of CAH, however levels may continue to rise immediately after birth, with further adrenal stimulation. An elevated 21DOC would confirm 21-hydroxylase deficiency CAH.

Sample Requirements and Reference Ranges

Sample type  Serum
Container  SST. Please send primary sample if possible. Some interference has been observed with certain aliquoter tubes, such as the Impeco tube.
Precautions  None
Minimum volume  160 μL (50 μL minimum for neonatal samples analysed in dilution)
Reference range

 Adult Females:

     Testosterone <1.5nmol/L

     17-Hydroxyprogesterone <6.0 nmo/L

     Androstenedione (18 - 40yrs) <5.5 nmol/L

     Androstenedione (>40yrs) <3.0 nmol/L

 Adult Males:

     Testosterone 7.0 - 30 nmol/L

     17-Hydroxyprogesterone <6.0 nmol/L

     Androstenedione <5.5 nmol/L

 Paediatric ranges under evaluation

Turnaround time  7 days (Please contact the lab to notify of any urgent neonatal  sample)
Method  Liquid chromatography-tandem mass spectrometry
 
Quality Assurance
UK NEQAS