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Dehydroepiandrosterone sulphate (DHEAS)

Dehydroepiandrosterone sulphate (DHEAS) is the sulphated ester of the 19-carbon androgen DHEA, produced by the adrenal gland. DHEAS is the most abundant circulating androgen and shows no diurnal rhythm. DHEAS acts as a precursor to other androgens, such as androstenedione and testosterone.

Measurement of DHEAS may be of benefit for the investigation of excess androgen. DHEAS is relatively specific for the adrenal glands, whereas other androgens, such as testosterone and androstenedione are also produced by the gonads.

Measurement of DHEAS is unhelpful in adult males.

Sample Requirements and Reference Ranges

Sample type  Serum or Plasma
Container SST or Lithium Heparin
Precautions  None
Minimum volume 2mL (100 uL minimum for paediatric samples)
Reference range

 

Pre-pubertal: <2.0 umol/L

Adult female <50 yr: ≤9.6 umol/L

Adult female  ≥50 yr: ≤3.1 umol/L

Turnaround time 14 days
Method Liquid chromatography-tandem mass spectrometry
 
Quality Assurance
UK NEQAS
Last Updated: 04 February 2021