Dehydroepiandrosterone sulphate (DHEAS) is the sulphated ester of the 19-carbon androgen DHEA, produced by the adrenal gland. DHEAS is the most abundant circulating androgen and shows no diurnal rhythm. DHEAS acts as a precursor to other androgens, such as androstenedione and testosterone.
Measurement of DHEAS may be of benefit for the investigation of excess androgen. DHEAS is relatively specific for the adrenal glands, whereas other androgens, such as testosterone and androstenedione are also produced by the gonads.
Measurement of DHEAS is unhelpful in adult males.
Sample Requirements and Reference Ranges
|Sample type||Serum or Plasma|
|Container||SST or Lithium Heparin|
|Minimum volume||2mL (100 uL minimum for paediatric samples)|
Pre-pubertal: <2.0 umol/L
Adult female <50 yr: ≤9.6 umol/L
Adult female ≥50 yr: ≤3.1 umol/L
|Turnaround time||14 days|
|Method||Liquid chromatography-tandem mass spectrometry|