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Bloodspot 17 - Hydroxyprogesterone

17-hydroxyprogesterone (17OHP) is one of the intermediary steroid metabolites in the cortisol biosynthetic pathway. The most common genetic defect in cortisol production is deficiency of the 21-hydroxlase enzyme, which leads to congenital adrenal hyperplasia (CAH). 17OHP concentrations are raised in this form of CAH (approximately 90% of CAH cases) and is a useful marker to monitor response to therapy. Measuring 17OHP in blood spot samples is less invasive than venepuncture and allows multiple samples to be taken over a 24hr period.

Blood spot 17OHP is not a diagnostic test and is only useful in monitoring treatment.

Sample requirements and reference range

Sample type  Whole blood spotted onto pre-prepared card available on request
Container  N/A
Precautions  None
Minimum volume  Ensure that blood soaks through to the back of the card
Reference range  N/A
Turnaround time  56 days
Method  Liquid chromatography - tandem mass spectrometry
Quality Assurance
Last Updated: 30 April 2019