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Aldosterone is produced in the zona glomerulosa of the adrenal glands in response to renin and angiotensin intermediates. Measurement of aldosterone is most useful in the investigation of hypertension when measured concurrently with renin so that an aldosterone/renin ratio may be calculated.

Beta blockers, diuretics, ACE inhibitors, angiotensin II receptor blockers, calcium channel blockers, a restricted salt diet and posture can affect interpretation of aldosterone results.

Sample Requirements and Reference Ranges

Sample type  Plasma
Container  EDTA
Precautions  Posture and relevant drug therapies (see above) may affect  interpretation of results.
Minimum volume  1.5 mL
Reference range

 Adults (upright): 130 - 800 pmol/L

 Neonates <1 month: 1000 - 5500 pmol/L

 Infants (1-6 months): 500 - 4500 pmol/L

 Infants (6-12 months): 160 - 3000 pmol/L

 Children (2-4 years): 130 - 1000 pmol/L

 Children (5-15 years): 130 - 600 pmol/L

Turnaround time  14 days
Method  IDS iSYS
Quality Assurance
Last Updated: 30 April 2019