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COVID-19 (Coronavirus info)

Information and guidance for public, NHSGGC staff, and community-based services.  Hospital visiting restrictions now in place.

TSH Receptor Antibody (TRAB)

TSH receptor antibody (TRAB) is measured if the cause of thyrotoxicosis is not clear. It is specific for Graves' autoimmune disease of thyroid but is not present in all cases. It can be used to distinguish Graves' disease from toxic multinodular goitre and postpartum or subacute thyroiditis. It is also measured in 3rd trimester of pregnancy, if there is a maternal history of Graves' disease/thyrotoxicosis, to predict risk of neonatal thyroid problems. It may be helpful in cases of possible "euthyroid" Graves' ophthalmopathy.

Sample Requirements and Reference Ranges

Sample type  Serum (plasma unsuitable)
Container  SST
Precautions  Lipaemic and haemolysed samples unsuitable
Minimum volume  2 mL
Reference range

 <2 U/L - negative

 ≥2 U/L - positive

Turnaround time  14 days
Method  RSR 3rd generation ELISA
Quality Assurance

Last Updated: 12 February 2020