Anti-TPO is present in 90-100% of patients with Hashimoto's thyroiditis, the commonest cause of autoimmune hypothyroidism. It is measured in patients with subclinical hypothyroidism (TSH 5-12 mIU/L and FT4 within reference limits: 8-21 pmol/L) to identify those at increased risk of developing thyroid failure. The risk of developing hypothyroidism if anti-TPO is positive is approximately 5% per year.
Sample Requirements and Reference Ranges
|Minimum volume||2 mL|
|Reference range||<6 IU/L|
|Turnaround time||1 day|