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Thyroperoxidase (TPO) Antibodies

Anti-TPO is present in 90-100% of patients with Hashimoto's thyroiditis, the commonest cause of autoimmune hypothyroidism. It is measured in patients with subclinical hypothyroidism (TSH 5-12 mIU/L and FT4 within reference limits: 8-21 pmol/L) to identify those at increased risk of developing thyroid failure. The risk of developing hypothyroidism if anti-TPO is positive is approximately 5% per year.

Sample Requirements and Reference Ranges

Sample type  Serum
Container  SST
Precautions  None
Minimum volume  2 mL
Reference range  <6 IU/L
Turnaround time  1 day
Method  Abbott Architect
 
Quality Assurance
UK NEQAS
Last Updated: 20 September 2019