NHS Greater Glasgow and Clyde is collaborating on the development of an accurate and reliable antibody test in the fight against COVID-19.
With involvement of clinicians, the biorepository team and coordinated through Scottish Health Innovations Ltd; a UK-based consortium is accelerating the development of a unique lateral flow test, supporting the requirement for reliable antibody testing at scale.
Based on existing prototypes developed for Zika virus and Dengue fever and work on the herpes simplex virus; this innovative solution will be tested and validated using blood samples from previously infected COVID-19 patients.
Using a finger prick blood sample, the test will establish if a person has acquired antibodies to the COVID-19 virus. The presence of antibodies as markers of viral immunity is widely used in clinical practice to indicate exposure to a virus and a degree of immunity.
Using a novel and highly sensitive lateral flow (pregnancy-test-like) design, the diagnostic will use capillary blood samples, which can be extracted by a lancet from a fingertip in any point of care location. It will take around 20 minutes to complete, providing a reliable and accurate result.
Dr John Goodfellow – Consultant Neuroimmunologist and Clinical Director of the Neuroimmunology Laboratory at the Queen Elizabeth University Hospital, Glasgow explains: “There are two contexts in which testing is required - diagnosis of active infection, and diagnosis of likely immunity to infection. We are specifically looking at immunity to infection and our unique lateral flow design has several innovative features that will produce a more accurate test than traditional designs, and can be rapidly adapted to viral mutations. Our approach also, reduces the development time and manufacturing cost of the product.”
The project is being developed through a new company, Coronex Limited, that brings together the collaboration of NHS Greater Glasgow and Clyde, Scottish Health Innovations Ltd, UK based biotechnology industry partners and Glasgow-based investment partner Axon Healthcare.
The test will be developed and manufactured in the UK, ensuring secure, cost effective supply to the NHS. It addresses the urgent need for a diagnostic which demonstrates high sensitivity and accuracy, and at speed, whether a person has acquired immunity to the COVID-19 virus.
Professor Julie Brittenden, Research and Development Director at NHS Greater Glasgow and Clyde comments: “I am so proud of our team of clinicians, research nurses, biorepository specialists and patients who have made it possible to kick-start the development of a brand new antibody test for COVID-19. This is part of our wider research and development efforts to improve the diagnosis and treatment of the virus which includes clinical trials and innovative projects and the wider R&D Team.”
Graham Watson, Executive Chairman at SHIL adds: “Testing is a nuanced and technical area. However, an expert team has been mobilised at speed and we are now supporting a rapid, robust process to create a prototype, test against clinical samples; and if successful, progress through regulatory approval to manufacture. We are hoping to roll out the test within 12-15 weeks; but must remain cognisant that we are innovating at speed within a healthcare setting and with evolving scientific evidence.”
Accurate and reliable testing is a key pillar of the COVID-19 response strategy around the world and a key component of the safe and managed easing of current lockdown restrictions.
For further information please contact [email protected], 0141 201 4467
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